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Completed and ongoing appraisals topics are listed below. Topics that were not accepted onto the appraisal work programme are also listed with the Topic Exploration Report (these do not include Evidence Appraisal Reports or guidance). Learn more about our appraisal process here.

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January 2024

Circulating tumour DNA tests for T790M mutations in non-small cell lung cancer

Circulating tumour DNA tests for T790M mutations in non-small cell lung cancer
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January 2024

Optical sensor devices for the detection of infiltration and extravasation of intravenous fluid

Optical sensor devices for the detection of infiltration and extravasation of intravenous fluid
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January 2024

Optical coherence tomography angiography for detection and diagnosis of vascular diseases of the eye

Optical coherence tomography angiography for detection and diagnosis of vascular diseases of the eye
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January 2024

Robot-assisted thoracic surgery

Robot-assisted thoracic surgery.
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December 2023

Radiofrequency renal denervation

Renal denervation to treat people with resistant hypertension
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December 2023

Solution-focused assessment tools

Solution-focused assessment tools for improving the treatment of people with severe mental illness within secondary mental health services.
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December 2023

Percutaneous implantation of pulmonary artery pressure sensors

Percutaneous implantation of pulmonary artery pressure sensors for monitoring treatment of chronic heart failure.
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December 2023

Automated pH testing to verify placement of nasogastric feeding tubes

Automated pH testing to verify placement of nasogastric feeding tubes
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December 2023

Clinical decision support software with integrated AI for the management of patients with incidental pulmonary nodules identified on chest CT scans (Optellum Virtual Node Clinic)

Clinical decision support software with integrated AI for the management of patients with incidental pulmonary nodules identified on chest CT…
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November 2023

Multi-grip upper limb prosthetics

Multi-grip myoelectric upper-limb prosthetics.
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September 2023

Myopia-control contact lenses and spectacles

Myopia-control contact lenses and spectacles to slow the progression of myopia in children and adolescents.
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September 2023

Digital cognitive assessment tools

Digital cognitive assessment tools to detect early-stage impairment caused by neurodegenerative disorders
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September 2023

Pre-emptive pharmacogenetic (PGx) testing using a multiple gene panel to guide treatment and reduce adverse drug reactions

Pre-emptive pharmacogenetic (PGx) testing using a multiple gene panel to guide treatment decisions
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September 2023

Hyperspectral imaging for the detection of cutaneous melanoma

Hyperspectral imaging for the detection of cutaneous melanoma
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September 2023

Photobiomodulation therapy for dry age-related macular degeneration

Use of near infrared spectrum light to in the treatment of dry age-related macular degeneration
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September 2023

Digital tools for the remote assessment of visual acuity

Digital tools for the remote assessment of visual acuity
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June 2023

IVUS (Intravascular ultrasound)

IVUS (Intravascular ultrasound) to guide percutaneous coronary intervention (PCI) for people with cardiovascular conditions
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June 2023

Urolon, a bioresorbable urethral bulking agent

Urolon, a bioresorbable urethral bulking agent for the treatment of stress urinary incontinence (SUI) among adult females.
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June 2023

MeMed BV testing to differentiate between bacterial and viral infections

MeMed BV testing to differentiate between acute bacterial and viral infection of the respiratory tract in the Hospital setting.
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June 2023

Smart peak flow meters

Smart peak flow meters for monitoring asthma.
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June 2023

Internet-based cognitive behavioural therapy in people with breast cancer

Internet-based cognitive behavioural therapy for mild-to-moderate depression or anxiety in people with breast cancer and survivors of breast cancer.
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June 2023

Spinal cord stimulation

Spinal cord stimulation for adults with chronic chemotherapy-induced peripheral neuropathy.
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June 2023

Wearable cardioverter defibrillators

Wearable cardioverter defibrillators for people at risk of cardiac death
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March 2023

Clinical decision tool with AI

A clinical decision support system with artificial intelligence (C the Signs) to facilitate early detection of cancer.
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March 2023

Digital companion robots

Digital companion robots to deliver remote care
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March 2023

Single pulse transcranial magnetic stimulation

Single pulse transcranial magnetic stimulation for the acute treatment or prevention of migraines.
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March 2023

Remote digital pose estimation

Remote digital pose estimation for orthopaedic injury or surgery
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March 2023

AI-assisted ultrasound

AI-assisted ultrasound for deep vein thrombosis
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March 2023

Photobiomodulation

Photobiomodulation for the prevention and treatment of oral mucositis associated with cancer treatment
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March 2023

Balloon dilation

Balloon dilation for chronic eustachian tube dysfunction
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March 2023

Cyanoacrylate glue occlusion

Cyanoacrylate glue occlusion for varicose veins.
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February 2023

Gracilis free-functioning muscle transfer

Gracilis free-functioning muscle transfer (FFMT) to restore upper limb function in brachial plexus injury
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February 2023

Ex-vivo lung perfusion

Ex-vivo lung perfusion for advanced pulmonary disease
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February 2023

Stereotactic radiosurgery

Stereotactic radiosurgery for trigeminal neuralgia
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February 2023

Electrical stimulation for people with chronic respiratory conditions, chronic heart failure and chronic kidney disease

Electrical stimulation to improve muscle strength and associated outcomes for people with chronic respiratory conditions, chronic heart failure and chronic…
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February 2023

Endoscopic balloon dilation

Endoscopic balloon dilation for subglottic or tracheal stenosis
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February 2023

Smartinhalers

Smartinhalers for people with asthma and other respiratory conditions
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February 2023

Personal SOS alarm wearables

Personal SOS alarm wearables for vulnerable and/or older people.
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February 2023

Retinal-based AI-enabled tool

Retinal-based AI-enabled tool to triage people at risk of cardiovascular disease
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February 2023

Digital psychological therapies

Digitally delivered psychological therapies for the treatment of depression
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February 2023

Electronic prescribing and medicines administration systems

Electronic prescribing and medicines administration systems for all secondary care inpatient and outpatient, including paediatric, settings.
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February 2023

Ambulatory patch electrocardiography monitoring devices

Ambulatory patch electrocardiography monitoring devices used to detect cardiac arrhythmias
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January 2023

Passive monitoring technologies to support the independence of older adults living alone

Passive monitoring technologies to support the independence of older adults living alone by identifying changes from normal routines and the…
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January 2023

Stereotactic ablative body radiotherapy (SABR) for locally advanced exocrine pancreatic cancer

Stereotactic ablative body radiotherapy (SABR) for locally advanced exocrine pancreatic cancer.
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January 2023

Leadless cardiac pacemakers for bradyarrhythmias

Leadless cardiac pacemakers for bradyarrhythmias due to contraindications for conventional pacemakers
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January 2023

Co-ordinated treatment or management plans

Co-ordinated treatment or management plans for people with multi-morbidities
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January 2023

Clinical decision support software (CDSS) during emergency telephone triage

Clinical decision support software (CDSS) during emergency telephone triage for people identified as lower urgency who may be able to…
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December 2022

Virtual reality distraction therapy

Virtual reality therapy for the management of procedure-related pain.
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December 2022

Virtual wards

Virtual wards to deliver care in community settings
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November 2022

Continuous topical oxygen therapy

Continuous topical oxygen therapy to treat people with chronic non-healing and complex diabetic foot ulcers
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October 2022

Left atrial appendage occlusion in patients with atrial fibrillation

Left atrial appendage occlusion in patients with atrial fibrillation
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October 2022

Genetic testing (prostate cancer)

Genetic testing for prostate cancer care.
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October 2022

Autofluorescence imaging

Adjunctive autofluorescence imaging of oral mucosal abnormalities to identify malignancy or premalignancy, including, but not limited to, OralID
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October 2022

Geniculate artery embolisation

Geniculate artery embolisation to relieve long-term pain for adults with knee osteoarthritis
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September 2022

Digital platform to support older people at home

Digital platforms for older people to support independent living and self-management in the home.
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September 2022

Minuteful Kidney test

Minuteful Kidney test for people at risk of chronic kidney disease (CKD)
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September 2022

Processed or cadaveric nerve allografts (PNA)

Processed or cadaveric nerve allografts (PNA) to repair peripheral nerve discontinuities for people with peripheral nerve damage.
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September 2022

T2 Magnetic Resonance

T2 Magnetic Resonance to aid early diagnosis of sepsis
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September 2022

RayPilot

RayPilot, a novel real-time electromagnetic tracking device, used during radiotherapy to treat prostate cancer.
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September 2022

Real-time continuous glucose monitoring

Real-time continuous glucose monitoring of people with type 1 and 2 diabetes
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September 2022

Stereotactic ablative body radiotherapy (SABR)

Stereotactic ablative body radiotherapy (SABR) for oligoprogressive disease.
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September 2022

WavelinQ EndoAVF System

WavelinQ EndoAVF System for haemodialysis access for people with end stage renal failure.
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August 2022

Interventions at the transition from children’s to adults’ services

Interventions at the transition from children’s to adults’ services for people with long-term conditions
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August 2022

Osseointegration

Osseointegration for people with transfemoral amputations.
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July 2022

Outpatient laryngeal biopsy

Laryngeal biopsies in the outpatient setting in people with suspected head and neck dysplasia/cancer
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July 2022

Closed loop systems

Closed loop systems for the management of type 1 diabetes
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June 2022

Continuous respiratory rate monitor (RespiraSense)

A continuous respiratory rate monitor (RespiraSense) for people with multiple respiratory conditions.
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June 2022

Stereotactic ablative radiotherapy (SABR)

Stereotactic ablative radiotherapy (SABR) for the treatment of renal cell carcinoma
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June 2022

Powered lower limb exoskeletons

Powered lower limb exoskeletons to support the musculoskeletal system in adults and children with complex neurological impairments or spinal cord…
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June 2022

Interactive therapeutic devices/doll therapy (HUG)

Interactive therapeutic devices (doll therapy) in advanced dementia care
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June 2022

Remote monitoring with robotic-assist knee balancing system

Remote patient monitoring (RPM) with the robotic-assist knee balancing system for people undergoing total knee replacement arthroplasty
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June 2022

Prescription delivery application

Delivery tracking application for prescription deliveries
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June 2022

Hospital discharge services (Hospital to a Healthier Home)

Hospital discharge services to help make housing safe and accessible for older people
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June 2022

Bed monitoring and alarm systems in care homes

Bed monitoring systems to prevent falls and pressure injury in care homes.
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May 2022

Video laryngoscopes

Video laryngoscopes for use in pre-hospital care.
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May 2022

Electronic blood management systems

Electronic blood management systems for blood transfusions
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May 2022

Tumour profiling tests

Tumour profiling tests that guide treatment decisions for early breast cancer
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May 2022

DeltaScan Brain State Monitor

DeltaScan Brain State Monitor for the diagnosis of acute encephalopathy and/or delirium
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May 2022

Extreme HypoFractionated Radiotherapy (EHFRT)

Extreme HypoFractionated Radiotherapy (EHFRT) for localised prostate cancer
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April 2022

Colourimetry

Colourimetry interventions to support people with visual stress
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March 2022

Convalescent Plasma Therapy for the Treatment of COVID-19

Convalescent plasma therapy for people with COVID-19
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March 2022

CaRi-Heart

CaRi-Heart for measurement of coronary inflammation in the investigation and management of coronary artery disease
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February 2022

Guided and non-guided self-help for social anxiety disorder

Individual guided and non-guided self-help for social anxiety disorder in children, adolescents and adults
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February 2022

LiverMultiScan

LiverMultiScan for the diagnosis and staging of non-alcoholic fatty liver disease (NAFLD)
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February 2022

Transcranial magnetic stimulation

Transcranial magnetic stimulation for the treatment of depression
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February 2022

Low carbohydrate dietary interventions

Low carbohydrate dietary interventions for people with type 2 diabetes, as part of a structured education programme
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February 2022

Neuropad

Neuropad for screening and detection of early signs of diabetic peripheral neuropathy
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January 2022

Portable devices that analyse mandibular movements for sleep apnoea diagnosis

Portable devices that analyse mandibular movements for the diagnosis of obstructive sleep apnoea
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January 2022

Cytoreduction surgery with hyperthermic intraoperative peritoneal chemotherapy

Cytoreduction surgery with hyperthermic intraoperative peritoneal chemotherapy for peritoneal carcinomatosis.
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January 2022

Selective internal radiation therapy

Selective internal radiation therapy for metastatic colorectal cancer.
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January 2022

Active transcutaneous bone conduction hearing implants

Active transcutaneous bone conduction hearing implants for complex hearing conditions.
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January 2022

Use of neuroimaging for diagnosis of dementia

Structural neuroimaging for the diagnosis of dementia.
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January 2022

Active middle ear implants

Active middle ear hearing implants for complex hearing conditions.
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November 2021

Dynamic elastomeric fabric orthoses

Dynamic elastomeric fabric orthoses for neuromuscular disease and central nervous system conditions
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November 2021

Strategies for Relatives (START) intervention

Strategies for Relatives (START) intervention to improve the mental health of carers of people with dementia
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November 2021

Natriuretic peptides to rule-in and rule-out a diagnosis of acute heart failure

Natriuretic peptides to rule-in and rule-out a diagnosis of acute heart failure in adults in the emergency department setting
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October 2021

Clinical Photography applications

Clinical photography smartphone applications (apps) to assess patient posture of wheelchair users.
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October 2021

Education mobile applications – Pressure Ulcers

Digital applications to educate healthcare professionals about pressure ulcers
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October 2021

Remote triage of heart failure risk status

Heart failure risk status tool and telephone triage for remote monitoring of worsening heart failure.
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October 2021

Time Lapse embryo culture

Time-lapse systems for embryo incubation and assessment in assisted production
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