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Completed and ongoing appraisals topics are listed below. Topics that were not accepted onto the appraisal work programme are also listed with the Topic Exploration Report (these do not include Evidence Appraisal Reports or guidance). Learn more about our appraisal process here.

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August 2026

Intranasal photodisinfection

Intranasal photodisinfection for the prevention of surgical site infections
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August 2026

Compression systems for lower limb ulcers and oedema

Multicomponent compression systems in a single bandage for lower limb ulcers and oedema
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August 2026

Pharmacogenomic tests to predict clozapine response

Pharmacogenomic tests to predict clozapine response in treatment-resistant schizophrenia
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August 2026

Finger-worn sensors to diagnose and monitor sleep-disordered breathing

Finger-worn sensors to diagnose and monitor sleep-disordered breathing in children and adults
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August 2026

Pharyngeal electrical stimulation

Pharyngeal electrical stimulation for swallowing difficulties resulting from neurogenic disorders in adults
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August 2026

Clinical hyperthermia alongside radiotherapy and/or chemotherapy

Clinical hyperthermia alongside radiotherapy and/or chemotherapy for recurrent breast cancer
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August 2026

Blood-based liquid biopsies

Blood-based liquid biopsies that analyse circulating stem cells and associated molecular markers for early cancer detection and triage
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August 2026

Chemosaturation for uveal melanoma liver Metastases

Chemosaturation with percutaneous hepatic perfusion of melphalan for liver metastases from uveal melanoma
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July 2026

Epileptic seizure alarms

Wearable and bed-based technologies to detect tonic-clonic seizures in people with epilepsy
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July 2026

Rapid antigen detecting tests

Rapid antigen detection tests for group A streptococcal infections to treat people with a sore throat in the community pharmacy…
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June 2026

DNA methylation-based biomarkers from circulating tumour DNA

DNA methylation-based biomarkers from circulating tumour DNA for the diagnosis of pancreatic cancer
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June 2026

Remote triage of heart failure

Remote triage of heart failure using cardiac implantable electronic devices
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June 2026

Water-filtered infrared radiation hyperthermia

Water-filtered infrared radiation hyperthermia for the treatment of locally recurrent breast cancer
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June 2026

Urethral catheter safety valves

Urethral catheter safety valves
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June 2026

Chyme reinfusion therapy

Chyme reinfusion therapy for type 2 intestinal failure after bowel surgery
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June 2026

Multi gene blood-based methylation tests

Multi gene blood-based methylation tests for the screening of colorectal cancer
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June 2026

Spinal braces

Spinal braces for mid-thoracic stable fractures
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June 2026

Cone-beam breast computed tomography

Cone-beam computed tomography for breast imaging in people with suspected breast cancer
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April 2026

Controlled dynamic stretch orthoses

Controlled dynamic stretch orthoses for postoperative knee stiffness and arthrofibrosis
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April 2026

Static progressive stretch orthoses

Static progressive stretch orthoses for postoperative knee stiffness and arthrofibrosis
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April 2026

Dynamic elastomeric fabric orthoses

Dynamic elastomeric fabric orthoses for children and young people with neurological conditions
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April 2026

Salvage high-dose-rate brachytherapy (HDR-BT)

Salvage high-dose-rate brachytherapy (HDR-BT) for localised relapse of prostate cancer after prior curative intent radiotherapy.
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April 2026

Artificial intelligence-assisted ultrasound

Artificial intelligence-assisted ultrasound for the detection of deep vein thrombosis
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April 2026

Continuous wireless monitoring in enhanced community care at home

Continuous wireless monitoring of vital signs for enhanced community care at home
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April 2026

Total body photography

Total body photography using AI assisted imaging systems to identify skin melanoma in secondary care
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March 2026

Waterjet ablation therapy

Robotic waterjet ablation therapy for lower urinary tract symptoms caused by benign prostatic hyperplasia.
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March 2026

Automated oxygen titration

Automated oxygen titration in oxygen treatment
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March 2026

Multiplex polymerase chain reaction tests on synovial fluid

Multiplex polymerase chain reaction tests on synovial fluid for diagnosing joint infections
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March 2026

Cyclically pressurised topical wound oxygen therapy

Cyclically pressurised topical wound oxygen therapy for hard-to-heal wounds
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March 2026

Continuous wireless monitoring in hospital

Continuous wireless monitoring of vital signs on general wards
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March 2026

PrecivityAD2 blood test

PrecivityAD2 blood test for the assessment of Alzheimer’s Disease
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March 2026

Biodegradable rectal spacers

Biodegradable rectal spacers for use during radiotherapy for prostate cancer
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February 2026

Electronic fetal monitoring with the help of Artificial Intelligence

Electronic fetal monitoring with the help of Artificial Intelligence
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February 2026

Transcranial direct current stimulation

Transcranial direct current stimulation (tDCS) for depression
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February 2026

Behaviour change apps

Behaviour change apps for chronic conditions
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February 2026

Optimal vein selection

Methods for optimal vein selection for peripheral intravenous cannulation
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February 2026

Hydrogel coating for orthopaedic implants

Hydrogel coating to reduce orthopaedic implant-related infection in people at higher risk of infection.
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February 2026

Therapeutic supportive restraint devices as an alternative to traditional manual restraint

Therapeutic supportive restraint devices such as the safety pod, as an alternative to traditional manual restraint across a variety of…
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January 2026

Capsule sponge devices

Capsule sponge devices to detect Barrett’s oesophagus and early-stage oesophageal cancer
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December 2025

MAF-gene tests to guide adjuvant bisphosphonate treatment in breast cancer

MAF-gene tests to guide adjuvant bisphosphonate treatment in breast cancer
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December 2025

Thermal ablation of colorectal liver metastases

Thermal ablation of liver metastases in people with colorectal cancer
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October 2025

Nitric oxide-generating wound dressings

Nitric oxide-generating wound dressings for diabetic foot ulcers
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October 2025

Point-of-care portable, digital endoscopes

Point-of-care portable, digital endoscopes for people with lower gastrointestinal (GI) symptoms in primary care
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October 2025

Digital interventions for chronic kidney disease

Digital rehabilitation and self-management interventions for chronic kidney disease.
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October 2025

At-home video monitoring for epilepsy

At-home video monitoring for the diagnosis and management of epilepsy
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October 2025

Carer passport schemes

Carer passport schemes to identify and offer support, benefits and resources to carers.
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October 2025

Oral neuromuscular training devices for the treatment of dysphagia

Oral neuromuscular training devices for the treatment of dysphagia
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October 2025

Haemodialysis at home

Portable home dialysis systems
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October 2025

Digital population health management and risk stratification tools

Digital population health management and risk stratification tools
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October 2025

Oral neuromuscular training devices for the treatment of hiatus hernia or reflux

Oral neuromuscular training devices for the treatment of hiatus hernia or reflux
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August 2025

Long length peripheral intravenous catheters

Long length peripheral intravenous catheters for patients with difficult intravenous access
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August 2025

Photoplethysmography for the management of atrial fibrillation

Photoplethysmography for the management of atrial fibrillation
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July 2025

Electroencephalogram neurofeedback systems

Electroencephalogram neurofeedback systems for chronic pain
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July 2025

Inherited cancer registries

Registries for the identification, tracking and surveillance of people at risk of inherited cancers
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July 2025

Implantable tibial neuromodulation devices

Implantable tibial neuromodulation devices for treatment of urge urinary incontinence
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June 2025

Digital tools incorporating cognitive eye vergence markers to diagnose attention deficit hyperactivity disorder (ADHD) in adults and children

BGaze Clinic by BrainGaze is a computerised ADHD assessment. It takes 12 minutes to complete and involves using an eye…
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June 2025

Raman spectroscopy blood tests

Raman spectroscopy blood test combined with machine learning to identify colorectal cancer
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June 2025

AI-assisted pathology for gastric cancer biopsies

AI-assisted pathology to triage suspected gastric cancer biopsies
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June 2025

Online adaptive radiotherapy

Online adaptive radiotherapy in the treatment of cancer
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June 2025

Probiotic cleaning products

Probiotic cleaning products to reduce health-care associated infections in hospital settings
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June 2025

Smartwatches for atrial fibrillation

Smartwatches for the detection of atrial fibrillation
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May 2025

Advanced electrosurgical bipolar vessel sealing systems during hysterectomy

Use of advanced electrosurgical bipolar vessel sealing systems during hysterectomy compared to other methods for control of bleeding.
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May 2025

AMBLor

AMBLor for identifying low-risk non-ulcerated early-stage cutaneous melanomas
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April 2025

Superior rectal artery embolisation for haemorrhoids

Superior rectal artery embolisation for the treatment of haemorrhoids.
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April 2025

Permanent implant brachytherapy devices for unresectable pancreatic cancer

Permanent implant brachytherapy devices for the treatment of locally advanced, unresectable pancreatic cancer
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April 2025

Point-of-care blood glucose monitoring systems for hypoglycaemia in neonates

Point-of-care blood glucose monitoring systems for diagnosis and management of hypoglycaemia in neonates
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April 2025

Gender affirming surgery

Gender affirming surgery for trans people
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April 2025

Leadless cardiac pacemakers

Leadless cardiac pacemakers for bradyarrhythmia
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April 2025

PrecivityAD blood test

PrecivityAD blood test for the assessment of Alzheimer’s Disease
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April 2025

AI assisted review of chest x-ray and CT scans

AI assisted review of chest x-ray and CT scans in the diagnosis of lung cancer
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March 2025

Multiparametric magnetic resonance imaging

Multiparametric magnetic resonance imaging compared with biparametric magnetic resonance imaging for the detection of prostate cancer
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March 2025

Telemetric intracranial pressure monitoring

Long-term telemetric intracranial pressure monitoring for diagnosis and treatment optimisation of neurological conditions
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January 2025

Catheter locking solutions

Non antibiotic antimicrobial anticoagulant catheter locking solutions for the prevention of catheter related complications
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December 2024

Digital tools for diabetes management

Digital platforms for personalised diabetes management, education and support in adults
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December 2024

Artificial intelligence-assisted mammography reading (FxMammo)

Artificial intelligence-assisted mammography reading in the detection of breast cancer (FxMammo)
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December 2024

Body-worn sensor monitoring

Body-worn sensor monitoring for people receiving inpatient mental health services.
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December 2024

Non-contact, room-based monitoring

Non-contact, room-based monitoring for people receiving inpatient mental health services
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December 2024

Robot-assisted benign gynaecological surgery

Robot assisted benign gynaecological surgery
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December 2024

ELF test (Enhanced Liver Fibrosis)

The Enhanced Liver Fibrosis test for diagnosing advanced fibrosis in metabolic dysfunction-associated steatotic liver disease.
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November 2024

Hybrid Convergent ablation

Hybrid Convergent ablation for the treatment of atrial fibrillation
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November 2024

Anti-ligature products and devices

Anti-ligature products and devices to reduce suicide and self-harm.
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November 2024

PocDoc

PocDoc digital point-of-care cholesterol testing for cardiovascular disease risk assessment and management.
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November 2024

Contactless photoplethysmography using smart devices

Contactless photoplethysmography for measuring blood pressure using cameras on smart phones or tablets and artificial intelligence software.
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November 2024

Gastroelectrical stimulation for the treatment of gastroparesis

Gastroelectrical stimulation for the treatment of adults with severe, intractable gastroparesis.
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November 2024

Advanced paramedic practitioners

Advanced paramedic practitioners for assessment and treatment of medical emergencies
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September 2024

Leakage notification systems for stoma care

Systems to warn people of leakage before it seeps beyond the stoma baseplate.
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August 2024

Linus Health Core Cognitive Evaluation digital assessment

Linus Health Core Cognitive Evaluation digital assessment to detect cognitive impairment.
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August 2024

Virtual reality as a psychological intervention

Virtual reality interventions to support people with mental health difficulties and/or neurodevelopmental conditions.
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August 2024

Auditory verbal therapy

Auditory verbal therapy for young children who are deaf and hard of hearing.
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August 2024

Perineal and pelvic rehabilitation

Perineal and pelvic rehabilitation for the prevention and treatment of anorectal dysfunction, pelvic organ prolapse and perineal pain in women.
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August 2024

Deontics Cancer MDT solution

Deontics Cancer MDT solution to streamline and support multi-disciplinary team meetings.
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August 2024

Autologous blood microfiltration systems

Autologous blood microfiltration systems for peri- and post-operative cell.
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August 2024

Artificial intelligence assisted tools for prostate cancer diagnosis using whole slide biopsy images

Artificial intelligence assisted tools for prostate cancer diagnosis using whole slide biopsy images
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July 2024

Floseal in the treatment of epistaxis

Floseal is a bioresorbable topical haemostatic agent which can be used in the treatment of epistaxis (nosebleeds) if first aid…
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July 2024

Hip protectors

Hip Protectors for users at risk of falls
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July 2024

Wearable wound care for hidradenitis suppurativa

Wearable wound care for hidradenitis suppurativa
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July 2024

AI prediction of fatty liver disease from laboratory test results

Artificial intelligence-interpretation of laboratory test results to predict fatty liver disease in primary care.
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July 2024

Interventions to prevent and reduce gang-related violence

Interventions to prevent and reduce gang-related violence in children and young adults.
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July 2024

National Early Warning Score systems in acute care

National Early Warning Score systems (NEWS and NEWS2) for adult patients across the acute care pathway.
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July 2024

Wire-Free, Nonradioactive Localisation Techniques

Wire-Free, Nonradioactive Localisation Techniques to Guide Surgical Excision of Nonpalpable Breast Tumours.
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